GenDR Dietary Restriction Gene Manipulation: jun-1
Gene Information (Entrez Gene ID: 174452)
- JUN transcription factor homolog
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
Potential relevance to dietary restriction and ageing
Loss-of-function jun-1 mutant or inhibition of jun-1 by post-developmental RNA interference reduces the lifespan extension of intermitent fasting. In the wild-type N2 worms, intermitent fasting increases lifespan by ~77%, while in the jun-1 mutants lifespan extension is reduced to 29-32%. Contrastly, the lifespan of daf-2 mutants is unaffected by jun-1 RNA interference. Although jun-1 mutants are also shorter lived than wild-type N2s, the fact that jun-1 mutation/interference selectively affects lifespan extension by intermitent fasting, but not daf-2 lifespan extension, suggests that jun-1 plays a role in dietary restriction. Similar results are observed for fos-1 mutants, or the jun-1, fos-1 double RNA interference.