GenDR Dietary Restriction Gene Manipulation: FKH1
Gene Information (Entrez Gene ID: 854675)
- ForK head Homolog 1
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
Potential relevance to dietary restriction and ageing
Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan . Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in a slight increased chronological and replicative lifespan as well as stress resistance .