GenDR Dietary Restriction Gene Manipulation: Thor
Gene Information (Entrez Gene ID: 33569)
- Symbol
- Thor
- Aliases
- 153432_at 43-BP 4e-bp 4e-BP 4E-BP 4E-BP1 4ebp 4eBP 4EBP anon-WO0172774.158 BcDNA.HL08053 BcDNA:HL08053 CG8846 CT8705 d4e-bp d4E-BP d4E-BP1 d4eBP d4EBP Dm 4E-BP Dmel\CG8846 dthor eIF4E-BP l(2)06270 l(2)k07736 l(2)k13517 Phas1 pp20 thor Thor/EIF4EBP
- Name
- CG8846-PA
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 33569
Potential relevance to dietary restriction and ageing
- Observations
-
Null mutation in Thor (alias d4E-BP) causes a significant decrease in longevity (-25% median lifespan in males) [2579]. Thor is upregulated on the protein level in a foxo-independent manner upon DR, while it is transcriptionally induced in a foxo-dependent fashion by starvation. Thor null mutants cancel out DR-induced lifespan extension, because mutants exhibit a diminished change in lifespan when nutrient conditions were varied. Ubiquitously expression of Thor rescued DR response in females and males. Ubiquitously overexpression of wild-type Thor causes no change under ad libitum, but an activated allele (with more than 3-fold increased binding activity to delF4E) significantly extends lifespan of females (weak allele) and females as well as males (strong allele). Mean lifespan is extended by 11 to 40%. Median lifespan of males and females is enhanced by 11 and 22%, respectively. Maximum lifespan is extended by 16 and 18% for males and females, respectively. Under DR (0.25% YE) there is no lifespan extension, beyond the effect of DR alone, in all (wild-type, weak and strong) Thor alleles [2547].
- References
-
In other databases
- GenAge model organism genes
- This gene is present as Thor
- LongevityMap
- A homolog of this gene for Homo sapiens is present as EIF4EBP1
- CellAge
- A homolog of this gene for Homo sapiens is present as EIF4EBP1
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as EIF4EBP1
Homologs
- Danio rerio
- eif4ebp3
- Danio rerio
- eif4ebp1
- Danio rerio
- eif4ebp2
- Danio rerio
- eif4ebp3l
- Homo sapiens
- EIF4EBP2
- Homo sapiens
- EIF4EBP3
- Homo sapiens
- EIF4EBP1
- Mus musculus
- Eif4ebp2
- Mus musculus
- Eif4ebp3
- Mus musculus
- Eif4ebp1
- Rattus norvegicus
- Eif4ebp2
- Rattus norvegicus
- Eif4ebp1
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 33569
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar