Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: gig

Gene Information (Entrez Gene ID: 40201)

Symbol
gig
Aliases
6975 C1 CG6975 Dmel\CG6975 dTsc2 dTSC2 gig|Tsc2 l(3)109 ME 109 tsc2 Tsc2 TSC2 Tsc2/gig
Name
gigas
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
40201

Potential relevance to dietary restriction and ageing

Observations

Overexpression of gig (alias dTsc2) increased mean lifespan by 20% at 25 degree and protected mutants from deleterious effects of rich food, as if mimicking the effect of DR. Lifespan extension was dependent on concentration of yeast extract in the diet with no or slight life extension observed at low concentrations [1317]. Additionally, overexpression of gig (Tsc2) in mated females flies, which results in the inactivation of TOR signaling, affects lifespan extension by methionine restriction. While at 1.0x diet (normal level of all amino-acids, 15% dietary yeast) methionine reduction (from 1mM to 0.2mM) shortened lifespan both for Tsc2 overexpressing and control flies, at a 0.4x diet (0.4x reduced levels of all amino acids, corresponding to 6% dietary yeast) methionine reduction resulted in a decreased lifespan but only for the Tsc2 overexpressing flies, suggesting in this case that methionine reduction and overexpressing Tsc2 share some common mechanisms [3474].

References

    In other databases

    GenAge model organism genes
    • This gene is present as gig
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as TSC2

    Homologs

    Danio rerio
    TSC2
    Homo sapiens
    TSC2
    Mus musculus
    Tsc2
    Rattus norvegicus
    Tsc2
    Schizosaccharomyces pombe
    tsc2

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 40201
    Homologues
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    UniProt
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    Internet
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