Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: pha-4

Gene Information (Entrez Gene ID: 180357)

Symbol
pha-4
Name
defective PHArynx development 4
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
180357

Potential relevance to dietary restriction and ageing

Observations

pha-4 is required for multiple forms of DR. RNAi of pha-4 decreases lifespan of wild-type worms and completely cancels out the lifespan extension of eat-2 mutants. Mutants of pha-4 do not respond to bacterial DR. Therefore, loss of pha-4 completely blocks the response to varying food concentration. Moreover, pha-4 expression is increased in response to DR. pha-4 overexpression increases longevity of wild-type only slightly, but significant that of daf-16 mutants [2340]. Intermittent fasting significantly extends lifespan of pha-4 [2566]. Solid DR extends lifespan of mutants with a temperature sensitive allele of pha-4 or pha-4 RNAi knockdown [2568]. PHA-4 appears to play a role in the life-extending effects of dietary restriction.

References

    In other databases

    GenAge model organism genes
    • This gene is present as pha-4
    • A homolog of this gene for Drosophila melanogaster is present as fkh

    Homologs

    Drosophila melanogaster
    fkh
    Homo sapiens
    FOXA3
    Homo sapiens
    FOXA1
    Mus musculus
    Foxa3
    Mus musculus
    Foxa1
    Rattus norvegicus
    Foxa3
    Rattus norvegicus
    Foxa1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 180357
    Homologues
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    UniProt
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    Internet
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