Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: hsp-12.6

Gene Information (Entrez Gene ID: 177778)

Symbol
hsp-12.6
Name
Heat Shock Protein
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
177778

Potential relevance to dietary restriction and ageing

Observations

hsp-12.6 loss-of-function mutation significantly extends lifespan under ad lib and significantly suppresses intermittent fasting-induced increase in lifespan, to a similar extend to that of daf-16 mutation. HSP-12.6 expression is induced by fasting in various tissues, including body wall muscle and neuronal systems. hsp-16.2 is one of downstream targets of DAF-16 in intermittent fasting-induced longevity. The extent of intermittent fasting-induced longevity in daf-16 hsp-12.6 double mutant is similar to that of single hsp-12.6 or daf-16 mutants [2566].

References

    In other databases

    GenAge model organism genes
    CellAge
    • A homolog of this gene for Homo sapiens is present as HSPB2
    CellAge gene expression
    • A homolog of this gene for Homo sapiens is present as HSPB8

    Homologs

    Danio rerio
    hspb3
    Danio rerio
    hspb15
    Danio rerio
    hspb2
    Danio rerio
    hspb1
    Danio rerio
    hspb8
    Danio rerio
    si:dkey-1k23.3
    Drosophila melanogaster
    l(2)efl
    Homo sapiens
    HSPB1
    Homo sapiens
    HSPB2
    Homo sapiens
    HSPB3
    Homo sapiens
    HSPB8
    Homo sapiens
    HSPB2-C11orf52
    Mus musculus
    Hspb2
    Mus musculus
    Hspb8
    Mus musculus
    Hspb1
    Mus musculus
    Hspb3
    Rattus norvegicus
    Hspb1
    Rattus norvegicus
    Hspb3
    Rattus norvegicus
    Hspb8
    Rattus norvegicus
    Hspb2

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    ID 177778
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar