Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: bec-1

Gene Information (Entrez Gene ID: 177345)

Symbol
bec-1
Name
BEClin (human autophagy) homolog 1
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
177345

Potential relevance to dietary restriction and ageing

Observations

bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [2250]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [2244] [2570].

References

    In other databases

    GenAge model organism genes
    • This gene is present as bec-1
    • A homolog of this gene for Saccharomyces cerevisiae is present as VPS30
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as VPS30

    Homologs

    Danio rerio
    becn1
    Drosophila melanogaster
    Atg6
    Homo sapiens
    BECN2
    Homo sapiens
    BECN1
    Mus musculus
    Gm38100
    Mus musculus
    Becn1
    Rattus norvegicus
    Becn2
    Rattus norvegicus
    Becn1
    Saccharomyces cerevisiae
    VPS30
    Schizosaccharomyces pombe
    atg6

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 177345
    Homologues
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    UniProt
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    Internet
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