Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Rpd3

Gene Information (Entrez Gene ID: 38565)

Symbol
Rpd3
Aliases
CG7471 dHDAC-1 dHDAC1 DHDAC1 Dmel\CG7471 dmHDA401 DmHDAC1 drpd3 dRpd3 dRPD3 DRpd3 E(var)3-64BC HDAC HDAC-1 hdac1 Hdac1 HDAC1 l(3)04556 l(3)64Cc rpd3 RPD3 Rpd3/HDAC rpd[3] Su(var)3-26 Su(var)326 Su(var)328
Name
Histone deacetylase Rpd3
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
38565

Potential relevance to dietary restriction and ageing

Observations

Males heterozygous for hypomorphic or null mutation of Rpd3 have a lifespan extension of 33% and 41 - 47%, respectively. Females heterozygous for a hypomorphic allele have a 52% increase in lifespan, but females carrying a null mutation have only modest increase in maximum lifespan (but not median lifespan). Longevity increases to the same extent in wild-type under low-calorie diet and rpd3 mutants fed normal diet. DR fails to further increase lifespan of rpd3 mutants. DR leads to a moderate but significant down-regulation of Rpd3, analogous to decrease obtained in heterozygotes carrying rpd3 mutation. rpd3 mutants fed normal food and wild-type fed low-calorie increase Sir2 expression two-fold [202].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
    • This gene is present as Rpd3
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as HDAC1
    • A homolog of this gene for Homo sapiens is present as HDAC2
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
    CellAge
    • A homolog of this gene for Homo sapiens is present as HDAC1

    Homologs

    Caenorhabditis elegans
    hda-1
    Caenorhabditis elegans
    hda-3
    Danio rerio
    hdac1
    Homo sapiens
    HDAC1
    Homo sapiens
    HDAC2
    Mus musculus
    Hdac1
    Mus musculus
    Hdac2
    Mus musculus
    Gm10093
    Rattus norvegicus
    Hdac2
    Rattus norvegicus
    Hdac1l
    Rattus norvegicus
    Hdac1
    Saccharomyces cerevisiae
    RPD3
    Schizosaccharomyces pombe
    clr6

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 38565
    Homologues
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    UniProt
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    Internet
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