Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: LAT1

Gene Information (Entrez Gene ID: 855653)

Symbol
LAT1
Aliases
ODP2 PDA2
Name
dihydrolipoyllysine-residue acetyltransferase
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
855653

Potential relevance to dietary restriction and ageing

Observations

LAT1 is suggested to play a role in lifespan extension of DR. Deleting LAT1 abolishes replicative lifespan extension induced by 0.5% and 0.05% glucose restriction. In contrast, overexpressing Lat1 extends replicative lifespan, and this lifespan extension was not further increased by 0.5% glucose restriction. Similar to DR, replicative lifespan extension by LAT1 overexpression largely requires mitochondrial respiration [2317]. Interestingly, LAT1 overexpression does not require the Sir2 family to extend lifespan. Lat1 is also a limiting longevity factor in non-dividing cells in that overexpressing LAT1 extends cell survival during prolonged culture at stationary phase.

References

    In other databases

    GenAge model organism genes
    • This gene is present as LAT1
    • A homolog of this gene for Caenorhabditis elegans is present as dlat-1

    Homologs

    Caenorhabditis elegans
    dlat-1
    Caenorhabditis elegans
    C30H6.7
    Danio rerio
    dlat
    Danio rerio
    pdhx
    Drosophila melanogaster
    CG5261
    Homo sapiens
    PDHX
    Homo sapiens
    DLAT
    Mus musculus
    Pdhx
    Mus musculus
    Dlat
    Rattus norvegicus
    Dlat
    Rattus norvegicus
    Pdhx
    Schizosaccharomyces pombe
    lat1

    External links

    Saccharomyces Genome Database
    Search
    Ensembl
    Search
    Entrez Gene
    ID 855653
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar