Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: HXK2

Gene Information (Entrez Gene ID: 852639)

Symbol
HXK2
Aliases
HEX1 HKB SCI2
Name
HeXoKinase 2
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
852639

Potential relevance to dietary restriction and ageing

Observations

Deletion of HXK2 extends mean and maximum replicative lifespan by about 53% and 33%, respectively. Limiting glucose availability by mutating HXK2 significantly extends replicative lifespan and provides a genetic model of DR [2260]. HXK2 mutants have a transcriptional profile that significantly resembles DR cells [2274].

References

    In other databases

    GenAge model organism genes
    • This gene is present as HXK2
    • A homolog of this gene for Drosophila melanogaster is present as Hex-A
    • A homolog of this gene for Drosophila melanogaster is present as Hex-C
    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Gck
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Hex-C
    CellAge
    • A homolog of this gene for Homo sapiens is present as HK3

    Homologs

    Caenorhabditis elegans
    hxk-2
    Caenorhabditis elegans
    hxk-1
    Caenorhabditis elegans
    hxk-3
    Danio rerio
    hkdc1
    Danio rerio
    gck
    Danio rerio
    hk1
    Danio rerio
    hk2
    Drosophila melanogaster
    Hex-A
    Drosophila melanogaster
    Hex-t1
    Drosophila melanogaster
    Hex-t2
    Drosophila melanogaster
    Hex-C
    Homo sapiens
    HK2
    Homo sapiens
    HK3
    Homo sapiens
    HKDC1
    Homo sapiens
    HK1
    Homo sapiens
    GCK
    Mus musculus
    Hk3
    Mus musculus
    Hkdc1
    Mus musculus
    Hk1
    Mus musculus
    Hk2
    Mus musculus
    Gck
    Rattus norvegicus
    LOC100364027
    Rattus norvegicus
    Hk1
    Rattus norvegicus
    Hk2
    Rattus norvegicus
    Hk3
    Rattus norvegicus
    Gck

    External links

    Saccharomyces Genome Database
    Search
    Ensembl
    Search
    Entrez Gene
    ID 852639
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar