Cell Senescence Entries for ALDOA

Cell Types
Colorectal cancer, Melanoma
Cell Lines
A375P, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

ALDOA Gene Information

HGNC symbol
ALDOA 
Aliases
 
Common name
aldolase, fructose-bisphosphate A 
Entrez Id
226
Description
This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017].

ALDOA Ontologies

Gene Ontology
Process: GO:6096; glycolytic process
GO:30388; fructose 1,6-bisphosphate metabolic process
GO:51289; protein homotetramerization
GO:46716; muscle cell cellular homeostasis
GO:6000; fructose metabolic process
GO:6754; ATP biosynthetic process
GO:6941; striated muscle contraction
GO:7015; actin filament organization
GO:7339; binding of sperm to zona pellucida
GO:8360; regulation of cell shape
Cellular component: GO:5829; cytosol
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5615; extracellular space
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:31430; M band
GO:31674; I band
GO:15629; actin cytoskeleton
GO:34774; secretory granule lumen
And 5 more GO terms
Function: GO:3824; catalytic activity
GO:4332; fructose-bisphosphate aldolase activity
GO:3723; RNA binding
GO:16829; lyase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:45296; cadherin binding
GO:3779; actin binding
GO:8092; cytoskeletal protein binding
GO:15631; tubulin binding
GO:70061; fructose binding
And 1 more GO terms
Show all GO terms

Homologs of ALDOA in Model Organisms

Caenorhabditis elegans
aldo-1
Caenorhabditis elegans
aldo-2
Danio rerio
aldoab
Danio rerio
aldoaa
Drosophila melanogaster
Ald
Drosophila melanogaster
CG5432
Mus musculus
Aldoart1
Mus musculus
Aldoart2
Mus musculus
Aldoa
Rattus norvegicus
Aldoa
Rattus norvegicus
AABR07040494.1
Rattus norvegicus
Aldoart2

External links

OMIM
103850
Ensembl
ENSG00000149925
Entrez Gene
226
UniGene
513490
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ALDOA
GeneCards
ALDOA