Cell Senescence Entries for AKR1B1

Cell Types
Keratinocyte
Cell Lines
HaCat
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Kang et al. (2011) Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation. Free Radic Biol Med 50(6)680-8 (PubMed)

AKR1B1 Gene Information

HGNC symbol
AKR1B1 
Aliases
ALDR1; AR 
Common name
aldo-keto reductase family 1 member B 
Entrez Id
231
Description
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009].

AKR1B1 Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:2070; epithelial cell maturation
GO:3091; renal water homeostasis
GO:35809; regulation of urine volume
GO:43066; negative regulation of apoptotic process
GO:72205; metanephric collecting duct development
GO:42572; retinol metabolic process
GO:22900; electron transport chain
GO:1523; retinoid metabolic process
GO:6693; prostaglandin metabolic process
GO:5975; carbohydrate metabolic process
And 6 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
GO:5615; extracellular space
Function: GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:4032; alditol:NADP+ 1-oxidoreductase activity
GO:52650; NADP-retinol dehydrogenase activity
GO:47655; allyl-alcohol dehydrogenase activity
GO:9055; electron transfer activity
GO:1758; retinal dehydrogenase activity
GO:47956; glycerol dehydrogenase [NADP+] activity
GO:36130; prostaglandin H2 endoperoxidase reductase activity
GO:43795; glyceraldehyde oxidoreductase activity
Show all GO terms

Homologs of AKR1B1 in Model Organisms

Caenorhabditis elegans
ZC443.1
Caenorhabditis elegans
C07D8.6
Caenorhabditis elegans
C07D8.5
Caenorhabditis elegans
Y39G8B.2
Caenorhabditis elegans
T08H10.1
Caenorhabditis elegans
Y39G8B.1
Danio rerio
553452
Danio rerio
akr1b1
Drosophila melanogaster
CG6084
Mus musculus
Akr1b3
Rattus norvegicus
Akr1b1
Saccharomyces cerevisiae
GRE3

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as GRE3
CellAge gene expression
  • This gene is present as AKR1B1

External links

OMIM
103880
Ensembl
ENSG00000085662
Entrez Gene
231
UniGene
521212
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AKR1B1
GeneCards
AKR1B1