Cell Senescence Entries for ACKR1
- Cell Types
- Cerebral-microvascular endothelial
- Cell Lines
- HCEC
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Xu et al. (2008) Duffy antigen/receptor for chemokines (DARC) attenuates angiogenesis by causing senescence in endothelial cells. Angiogenesis 10(4)307-18 (PubMed)
ACKR1 Gene Information
- HGNC symbol
- ACKR1
- Aliases
- CCBP1; CD234; DARC; Dfy; FY; GPD
- Common name
- atypical chemokine receptor 1 (Duffy blood group)
- Entrez Id
- 2532
- Description
- The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
ACKR1 Ontologies
- Gene Ontology
-
Process: GO:7165; signal transduction
GO:7186; G protein-coupled receptor signaling pathway
GO:6954; inflammatory response
GO:6952; defense response
GO:70098; chemokine-mediated signaling pathway
GO:32642; regulation of chemokine production
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5768; endosome
GO:5769; early endosome
GO:55037; recycling endosome
GO:5886; plasma membrane
Function: GO:5515; protein binding
GO:4930; G protein-coupled receptor activity
GO:19956; chemokine binding
GO:38023; signaling receptor activity
GO:19957; C-C chemokine binding
GO:4888; transmembrane signaling receptor activity
Homologs of ACKR1 in Model Organisms
- Mus musculus
- Ackr1
External links
- OMIM
- 613665
- Ensembl
- ENSG00000213088
- Entrez Gene
- 2532
- UniGene
- 153381
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ACKR1
- GeneCards
- ACKR1