Cell Senescence Entries for ABCC6
- Cell Types
- Liver cancer
- Cell Lines
- Hep G2
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Miglionico et al. (2017) ABCC6 knockdown in HepG2 cells induces a senescent-like cell phenotype. Cell Mol Biol Lett 22(2)7 (PubMed)
ABCC6 Gene Information
- HGNC symbol
- ABCC6
- Aliases
- ARA; EST349056; MLP1; MRP6; PXE; URG7
- Common name
- ATP binding cassette subfamily C member 6
- Entrez Id
- 368
- Description
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008].
ABCC6 Ontologies
- Gene Ontology
-
Process: GO:55085; transmembrane transport
GO:50896; response to stimulus
GO:7601; visual perception
GO:10467; gene expression
GO:71716; leukotriene transport
GO:9410; response to xenobiotic stimulus
GO:15867; ATP transport
GO:46034; ATP metabolic process
GO:55062; phosphate ion homeostasis
GO:55074; calcium ion homeostasis
GO:30505; inorganic diphosphate transport
And 5 more GO terms Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:16323; basolateral plasma membrane
GO:5576; extracellular region
Function: GO:22857; transmembrane transporter activity
GO:166; nucleotide binding
GO:5524; ATP binding
GO:140359; ABC-type transporter activity
GO:42626; ATPase-coupled transmembrane transporter activity
GO:15431; ABC-type glutathione S-conjugate transporter activity
GO:43225; ATPase-coupled inorganic anion transmembrane transporter activity
Homologs of ABCC6 in Model Organisms
- Caenorhabditis elegans
- mrp-1
- Caenorhabditis elegans
- mrp-4
- Caenorhabditis elegans
- mrp-3
- Caenorhabditis elegans
- mrp-8
- Caenorhabditis elegans
- mrp-7
- Caenorhabditis elegans
- mrp-2
- Danio rerio
- abcc6a
- Danio rerio
- abcc6b.2
- Danio rerio
- abcc6b.1
- Drosophila melanogaster
- MRP
- Mus musculus
- Abcc6
- Rattus norvegicus
- Abcc6
- Saccharomyces cerevisiae
- YCF1
- Schizosaccharomyces pombe
- abc3
External links
- OMIM
- 603234
- Ensembl
- ENSG00000091262
- Entrez Gene
- 368
- UniGene
- 442182
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ABCC6
- GeneCards
- ABCC6