Cell Senescence Entries for ABCB1
- Cell Types
- Cervical cancer, Fibrosarcoma
- Cell Lines
- HeLa, HT1080
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Ruth et al. (2000) Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res 60(10)2576-8 (PubMed)
ABCB1 Gene Information
- HGNC symbol
- ABCB1
- Aliases
- ABC20; CD243; CLCS; GP170; MDR1; p-170; P-gp; PGY1
- Common name
- ATP binding cassette subfamily B member 1
- Entrez Id
- 5243
- Description
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017].
ABCB1 Ontologies
- Gene Ontology
-
Process: GO:55085; transmembrane transport
GO:6869; lipid transport
GO:150104; transport across blood-brain barrier
GO:140115; export across plasma membrane
GO:1990962; xenobiotic transport across blood-brain barrier
GO:45332; phospholipid translocation
GO:9410; response to xenobiotic stimulus
GO:86; G2/M transition of mitotic cell cycle
GO:46865; terpenoid transport
GO:47484; regulation of response to osmotic stress
GO:70633; transepithelial transport
And 7 more GO terms Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:16324; apical plasma membrane
GO:70062; extracellular exosome
GO:98591; external side of apical plasma membrane
GO:9986; cell surface
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:5515; protein binding
GO:140359; ABC-type transporter activity
GO:140326; ATPase-coupled intramembrane lipid transporter activity
GO:8559; ABC-type xenobiotic transporter activity
GO:42626; ATPase-coupled transmembrane transporter activity
GO:42910; xenobiotic transmembrane transporter activity
GO:15562; efflux transmembrane transporter activity
GO:90554; phosphatidylcholine floppase activity
GO:22857; transmembrane transporter activity
And 6 more GO terms
Homologs of ABCB1 in Model Organisms
- Caenorhabditis elegans
- pgp-2
- Danio rerio
- abcb4
- Drosophila melanogaster
- Mdr65
- Drosophila melanogaster
- CG10226
- Drosophila melanogaster
- Mdr50
- Drosophila melanogaster
- Mdr49
- Mus musculus
- Abcb1b
- Mus musculus
- Abcb1a
- Saccharomyces cerevisiae
- STE6
External links
- OMIM
- 171050
- Ensembl
- ENSG00000085563
- Entrez Gene
- 5243
- UniGene
- 689936
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ABCB1
- GeneCards
- ABCB1