Cell Senescence Entries for TACC3

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
RNAi-mediated depletion of TACC3 in breast carcinoma cells resulted in a progressive loss of the pro-apoptotic Bcl-2 protein Bim, upregulation of p21, downregulation of the RB and extracellular signal-regulated kinase 1/2, ultimately leading to cell arrest in the G1 phase. Cells showed a senescent phenotype including formation of SA-heterochromatin foci and increased SA-beta-galactosidase activity.
Primary Reference

    TACC3 Gene Information

    HGNC symbol
    TACC3 
    Aliases
    ERIC1; ERIC-1 
    Common name
    transforming acidic coiled-coil containing protein 3 
    Entrez Id
    10460
    Description
    This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]

    TACC3 Ontologies

    Gene Ontology
    Process: GO:51301; cell division
    GO:8283; cell proliferation
    GO:21987; cerebral cortex development
    GO:7091; metaphase/anaphase transition of mitotic cell cycle
    GO:1902850; microtubule cytoskeleton organization involved in mitosis
    GO:60236; regulation of mitotic spindle organization
    Cellular component: GO:5737; cytoplasm
    GO:15630; microtubule cytoskeleton
    GO:5815; microtubule organizing center
    GO:922; spindle pole
    Function: GO:5515; protein binding
    Show all GO terms

    Homologs of TACC3 in Model Organisms

    Danio rerio
    tacc3
    Mus musculus
    Tacc3
    Rattus norvegicus
    Tacc3

    In other databases

    CellAge gene expression
    • This gene is present as TACC3

    External links

    OMIM
    605303
    Ensembl
    ENSG00000013810
    Entrez Gene
    10460
    UniGene
    104019
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TACC3
    GeneCards
    TACC3