Cell Senescence Entries for SYK

Cell Types
Melanoma
Cell Lines
501-mel, A375, SK-MEL-28
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Bailet et al. (2009) Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest. Cancer Res 69(7)2748-56 (PubMed)

SYK Gene Information

HGNC symbol
SYK 
Aliases
 
Common name
spleen associated tyrosine kinase 
Entrez Id
6850
Description
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

SYK Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:35556; intracellular signal transduction
GO:2376; immune system process
GO:45087; innate immune response
GO:1775; cell activation
GO:1819; positive regulation of cytokine production
GO:1820; serotonin secretion
GO:1945; lymph vessel development
GO:2092; positive regulation of receptor internalization
GO:2223; stimulatory C-type lectin receptor signaling pathway
And 72 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
GO:19815; B cell receptor complex
GO:32009; early phagosome
GO:32991; protein-containing complex
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
GO:5634; nucleus
GO:42101; T cell receptor complex
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:19901; protein kinase binding
GO:19902; phosphatase binding
And 10 more GO terms
Show all GO terms

Homologs of SYK in Model Organisms

Danio rerio
syk
Drosophila melanogaster
shark
Mus musculus
Syk
Rattus norvegicus
Syk

In other databases

LongevityMap
  • This gene is present as SYK

External links

OMIM
600085
Ensembl
ENSG00000165025
Entrez Gene
6850
UniGene
371720
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SYK
GeneCards
SYK