Cell Senescence Entries for SRSF1

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Observations
Consistent with the stabilization of p53, increased SRSF1 expression in primary human fibroblasts decreased cellular proliferation and ultimately triggered oncogene-induced senescence (OIS).
Primary Reference

    SRSF1 Gene Information

    HGNC symbol
    SRSF1 
    Aliases
    ASF; SF2; SFRS1; SF2p33; SRp30a 
    Common name
    serine and arginine rich splicing factor 1 
    Entrez Id
    6426
    Description
    This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]

    SRSF1 Ontologies

    Gene Ontology
    Process: GO:6405; RNA export from nucleus
    GO:380; alternative mRNA splicing, via spliceosome
    GO:60048; cardiac muscle contraction
    GO:1701; in utero embryonic development
    GO:97421; liver regeneration
    GO:31124; mRNA 3'-end processing
    GO:395; mRNA 5'-splice site recognition
    GO:6406; mRNA export from nucleus
    GO:6397; mRNA processing
    GO:6376; mRNA splice site selection
    GO:398; mRNA splicing, via spliceosome
    And 4 more GO terms
    Cellular component: GO:71013; catalytic step 2 spliceosome
    GO:5737; cytoplasm
    GO:35145; exon-exon junction complex
    GO:70062; extracellular exosome
    GO:16607; nuclear speck
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:44547; DNA topoisomerase binding
    GO:3723; RNA binding
    GO:50733; RS domain binding
    GO:3729; mRNA binding
    GO:5515; protein binding
    GO:43422; protein kinase B binding
    Show all GO terms

    Homologs of SRSF1 in Model Organisms

    Caenorhabditis elegans
    rsp-3
    Danio rerio
    srsf1a
    Drosophila melanogaster
    SF2
    Mus musculus
    Srsf1
    Rattus norvegicus
    Srsf1
    Saccharomyces cerevisiae
    NPL3

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as NPL3

    External links

    OMIM
    600812
    Ensembl
    ENSG00000136450
    Entrez Gene
    6426
    UniGene
    68714
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SRSF1
    GeneCards
    SRSF1