Cell Senescence Entries for SRSF1

Cell Types
Foreskin fibroblast, Osteosarcoma
Cell Lines
BJ, U2OS
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Fregoso et al. (2013) Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. Mol Cell 50(1)56-66 (PubMed)

SRSF1 Gene Information

HGNC symbol
SRSF1 
Aliases
ASF; MGC5228; SF2; SF2p33; SFRS1; SRp30a 
Common name
serine and arginine rich splicing factor 1 
Entrez Id
6426
Description
This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014].

SRSF1 Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:51028; mRNA transport
GO:43484; regulation of RNA splicing
GO:398; mRNA splicing, via spliceosome
GO:395; mRNA 5'-splice site recognition
GO:380; alternative mRNA splicing, via spliceosome
GO:6376; mRNA splice site selection
Cellular component: GO:5634; nucleus
GO:5681; spliceosomal complex
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:71013; catalytic step 2 spliceosome
GO:35145; exon-exon junction complex
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:5515; protein binding
GO:3729; mRNA binding
GO:44547; DNA topoisomerase binding
Show all GO terms

Homologs of SRSF1 in Model Organisms

Caenorhabditis elegans
rsp-3
Danio rerio
srsf1a
Drosophila melanogaster
SF2
Mus musculus
Srsf1
Rattus norvegicus
Srsf1
Saccharomyces cerevisiae
NPL3

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as NPL3

External links

OMIM
600812
Ensembl
ENSG00000136450
Entrez Gene
6426
UniGene
710026
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SRSF1
GeneCards
SRSF1