Cell Senescence Entries for SRC

Cell Types
Fibrosarcoma
Cell Lines
HT1080
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
Overexpression of SRC lead to the inhibition of Adriamycin-induced senescence, including inhibition of G2-G1 checkpoints.
Primary Reference

    SRC Gene Information

    HGNC symbol
    SRC 
    Aliases
    ASV; SRC1; THC6; c-SRC; p60-Src 
    Common name
    SRC proto-oncogene, non-receptor tyrosine kinase 
    Entrez Id
    6714
    Description
    This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

    SRC Ontologies

    Gene Ontology
    Process: GO:38128; ERBB2 signaling pathway
    GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
    GO:31295; T cell costimulation
    GO:32148; activation of protein kinase B activity
    GO:34332; adherens junction organization
    GO:86098; angiotensin-activated signaling pathway involved in heart process
    GO:7411; axon guidance
    GO:45453; bone resorption
    GO:60444; branching involved in mammary gland duct morphogenesis
    GO:7049; cell cycle
    GO:8283; cell proliferation
    And 97 more GO terms
    Cellular component: GO:5884; actin filament
    GO:5901; caveola
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:31234; extrinsic component of cytoplasmic side of plasma membrane
    GO:5770; late endosome
    GO:5764; lysosome
    GO:5743; mitochondrial inner membrane
    GO:5739; mitochondrion
    GO:43005; neuron projection
    And 7 more GO terms
    Function: GO:5524; ATP binding
    GO:42169; SH2 domain binding
    GO:5070; SH3/SH2 adaptor activity
    GO:45296; cadherin binding
    GO:71253; connexin binding
    GO:19899; enzyme binding
    GO:46875; ephrin receptor binding
    GO:30331; estrogen receptor binding
    GO:70851; growth factor receptor binding
    GO:20037; heme binding
    GO:51427; hormone receptor binding
    And 16 more GO terms
    Show all GO terms

    Homologs of SRC in Model Organisms

    Caenorhabditis elegans
    src-1
    Danio rerio
    src
    Drosophila melanogaster
    Src64B
    Mus musculus
    Src
    Rattus norvegicus
    Src

    External links

    OMIM
    190090
    Ensembl
    ENSG00000197122
    Entrez Gene
    6714
    UniGene
    195659
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SRC
    GeneCards
    SRC