Cell Senescence Entries for SOCS1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Induces
Primary Reference
Calabrese et al. (2010) SOCS1 links cytokine signaling to p53 and senescence. Mol Cell 36(5)754-67 (PubMed)

SOCS1 Gene Information

HGNC symbol
SOCS1 
Aliases
Cish1; JAB; SOCS-1; SSI-1; TIP3 
Common name
suppressor of cytokine signaling 1 
Entrez Id
8651
Description
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].

SOCS1 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:35556; intracellular signal transduction
GO:9968; negative regulation of signal transduction
GO:43086; negative regulation of catalytic activity
GO:40008; regulation of growth
GO:43551; regulation of phosphatidylinositol 3-kinase activity
GO:19221; cytokine-mediated signaling pathway
GO:46426; negative regulation of receptor signaling pathway via JAK-STAT
GO:46854; phosphatidylinositol phosphate biosynthetic process
GO:42532; negative regulation of tyrosine phosphorylation of STAT protein
GO:1932; regulation of protein phosphorylation
And 13 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:31410; cytoplasmic vesicle
GO:5654; nucleoplasm
GO:36464; cytoplasmic ribonucleoprotein granule
GO:5942; phosphatidylinositol 3-kinase complex
GO:5829; cytosol
Function: GO:5515; protein binding
GO:46935; 1-phosphatidylinositol-3-kinase regulator activity
GO:19901; protein kinase binding
GO:5159; insulin-like growth factor receptor binding
GO:4860; protein kinase inhibitor activity
GO:19210; kinase inhibitor activity
Show all GO terms

Homologs of SOCS1 in Model Organisms

Danio rerio
socs1b
Danio rerio
socs1a
Drosophila melanogaster
Socs44A
Mus musculus
Socs1
Rattus norvegicus
Socs1

In other databases

LongevityMap
  • This gene is present as SOCS1

External links

OMIM
603597
Ensembl
ENSG00000185338
Entrez Gene
8651
UniGene
50640
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SOCS1
GeneCards
SOCS1