Cell Senescence Entries for SMAD3
- Cell Types
- Mammary epithelial
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Bryson et al. (2017) STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle 16(4)319-334 (PubMed)
SMAD3 Gene Information
- HGNC symbol
- SMAD3
- Aliases
- HsT17436; JV15-2; MADH3
- Common name
- SMAD family member 3
- Entrez Id
- 4088
- Description
- The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, Nov 2019].
SMAD3 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:7179; transforming growth factor beta receptor signaling pathway
GO:10628; positive regulation of gene expression
GO:45944; positive regulation of transcription by RNA polymerase II
GO:90101; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:90287; regulation of cellular response to growth factor stimulus
GO:122; negative regulation of transcription by RNA polymerase II
GO:165; MAPK cascade
GO:1501; skeletal system development
GO:1649; osteoblast differentiation
GO:1657; ureteric bud development
And 78 more GO terms Cellular component: GO:5634; nucleus
GO:5667; transcription regulator complex
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5637; nuclear inner membrane
GO:5886; plasma membrane
GO:32991; protein-containing complex
GO:785; chromatin
GO:43235; receptor complex
GO:71144; heteromeric SMAD protein complex
And 2 more GO terms Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:3700; DNA-binding transcription factor activity
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:3682; chromatin binding
GO:3690; double-stranded DNA binding
GO:5518; collagen binding
GO:8013; beta-catenin binding
And 30 more GO terms
Homologs of SMAD3 in Model Organisms
- Caenorhabditis elegans
- daf-8
- Caenorhabditis elegans
- sma-3
- Caenorhabditis elegans
- sma-2
- Danio rerio
- smad3b
- Danio rerio
- smad3a
- Drosophila melanogaster
- Smox
- Mus musculus
- Smad3
- Rattus norvegicus
- Smad3
In other databases
- GenAge model organism genes
External links
- OMIM
- 603109
- Ensembl
- ENSG00000166949
- Entrez Gene
- 4088
- UniGene
- 742270
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SMAD3
- GeneCards
- SMAD3