Cell Senescence Entries for SMAD2

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown, Mutation
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Gao et al. (2019) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 10(1)1665 (PubMed)

SMAD2 Gene Information

HGNC symbol
SMAD2 
Aliases
JV18-1; MADH2; MADR2 
Common name
SMAD family member 2 
Entrez Id
4087
Description
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

SMAD2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:7179; transforming growth factor beta receptor signaling pathway
GO:90101; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:90287; regulation of cellular response to growth factor stimulus
GO:35556; intracellular signal transduction
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:45165; cell fate commitment
GO:30509; BMP signaling pathway
And 44 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5667; transcription regulator complex
GO:785; chromatin
GO:5654; nucleoplasm
GO:5829; cytosol
GO:32991; protein-containing complex
GO:71144; heteromeric SMAD protein complex
GO:32444; activin responsive factor complex
GO:71141; SMAD protein complex
GO:71142; homomeric SMAD protein complex
And 3 more GO terms
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:19902; phosphatase binding
GO:3690; double-stranded DNA binding
GO:70412; R-SMAD binding
GO:3700; DNA-binding transcription factor activity
And 13 more GO terms
Show all GO terms

Homologs of SMAD2 in Model Organisms

Caenorhabditis elegans
sma-2
Caenorhabditis elegans
daf-8
Caenorhabditis elegans
sma-3
Danio rerio
smad2
Drosophila melanogaster
Smox
Mus musculus
Smad2
Rattus norvegicus
Smad2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-8
  • A homolog of this gene for Drosophila melanogaster is present as Smox

External links

OMIM
601366
Ensembl
ENSG00000175387
Entrez Gene
4087
UniGene
705764
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMAD2
GeneCards
SMAD2