Cell Senescence Entries for SIRT6
- Cell Types
- Chondrocyte
- Cell Lines
- NHAC-kn
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- SIRT6 inhibition significantly reduced proliferation and increased SA-beta-galactosidase positive chondrocytes. SIRT6 inhibition also led to increased p16 levels. Immunofluorescence microscopy showed that gamma-H2AX foci and TIFs were increased by SIRT6 inhibition.
- Primary Reference
SIRT6 Gene Information
- HGNC symbol
- SIRT6
- Aliases
- SIR2L6
- Common name
- sirtuin 6
- Entrez Id
- 51548
- Description
- This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
SIRT6 Ontologies
- Gene Ontology
-
Process: GO:6284; base-excision repair
GO:42593; glucose homeostasis
GO:1990619; histone H3-K9 deacetylation
GO:61647; histone H3-K9 modification
GO:8285; negative regulation of cell proliferation
GO:46325; negative regulation of glucose import
GO:45820; negative regulation of glycolytic process
GO:45892; negative regulation of transcription, DNA-templated
GO:1905555; positive regulation blood vessel branching
GO:1902732; positive regulation of chondrocyte proliferation
GO:31940; positive regulation of chromatin silencing at telomere
And 11 more GO terms Cellular component: GO:5737; cytoplasm
GO:5724; nuclear telomeric heterochromatin
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:5634; nucleus
Function: GO:3956; NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:3950; NAD+ ADP-ribosyltransferase activity
GO:70403; NAD+ binding
GO:17136; NAD-dependent histone deacetylase activity
GO:46969; NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:34979; NAD-dependent protein deacetylase activity
GO:3682; chromatin binding
GO:5515; protein binding
GO:3714; transcription corepressor activity
GO:8270; zinc ion binding
Homologs of SIRT6 in Model Organisms
- Caenorhabditis elegans
- sir-2.4
- Danio rerio
- SIRT6
- Drosophila melanogaster
- Sirt6
- Mus musculus
- Sirt6
- Rattus norvegicus
- Sirt6
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Sirt6
- GenAge human genes
- This gene is present as SIRT6
- LongevityMap
- This gene is present as SIRT6
External links
- OMIM
- 606211
- Ensembl
- ENSG00000077463
- Entrez Gene
- 51548
- UniGene
- 423756
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SIRT6
- GeneCards
- SIRT6