Cell Senescence Entries for SIRT3
- Cell Types
- Lung fibroblast
- Cell Lines
- WI-38
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Zhang et al. (2014) SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. Age (Dordr) 35(6)2237-53 (PubMed)
SIRT3 Gene Information
- HGNC symbol
- SIRT3
- Aliases
- SIR2L3
- Common name
- sirtuin 3
- Entrez Id
- 23410
- Description
- SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019].
SIRT3 Ontologies
- Gene Ontology
-
Process: GO:6476; protein deacetylation
GO:16575; histone deacetylation
GO:6471; protein ADP-ribosylation
GO:9060; aerobic respiration
GO:2000304; positive regulation of ceramide biosynthetic process
GO:34983; peptidyl-lysine deacetylation
GO:1901671; positive regulation of superoxide dismutase activity
GO:1902553; positive regulation of catalase activity
Cellular component: GO:32991; protein-containing complex
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5634; nucleus
GO:5654; nucleoplasm
Function: GO:46872; metal ion binding
GO:16740; transferase activity
GO:8270; zinc ion binding
GO:70403; NAD+ binding
GO:34979; NAD-dependent protein deacetylase activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:3950; NAD+ ADP-ribosyltransferase activity
GO:17136; NAD-dependent histone deacetylase activity
GO:51287; NAD binding
Homologs of SIRT3 in Model Organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as HST2
- GenAge human genes
- This gene is present as SIRT3
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as HST2
- LongevityMap
- This gene is present as SIRT3
External links
- OMIM
- 604481
- Ensembl
- ENSG00000142082
- Entrez Gene
- 23410
- UniGene
- 716456
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SIRT3
- GeneCards
- SIRT3