Cell Senescence Entries for SIRT3

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Zhang et al. (2014) SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. Age (Dordr) 35(6)2237-53 (PubMed)

SIRT3 Gene Information

HGNC symbol
SIRT3 
Aliases
SIR2L3 
Common name
sirtuin 3 
Entrez Id
23410
Description
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019].

SIRT3 Ontologies

Gene Ontology
Process: GO:6476; protein deacetylation
GO:16575; histone deacetylation
GO:6471; protein ADP-ribosylation
GO:9060; aerobic respiration
GO:2000304; positive regulation of ceramide biosynthetic process
GO:34983; peptidyl-lysine deacetylation
GO:1901671; positive regulation of superoxide dismutase activity
GO:1902553; positive regulation of catalase activity
Cellular component: GO:32991; protein-containing complex
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5634; nucleus
GO:5654; nucleoplasm
Function: GO:46872; metal ion binding
GO:16740; transferase activity
GO:8270; zinc ion binding
GO:70403; NAD+ binding
GO:34979; NAD-dependent protein deacetylase activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:3950; NAD+ ADP-ribosyltransferase activity
GO:17136; NAD-dependent histone deacetylase activity
GO:51287; NAD binding
Show all GO terms

Homologs of SIRT3 in Model Organisms

Danio rerio
sirt3
Mus musculus
Sirt3
Rattus norvegicus
Sirt3
Saccharomyces cerevisiae
HST2

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as HST2
GenAge human genes
  • This gene is present as SIRT3
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as HST2
LongevityMap
  • This gene is present as SIRT3

External links

OMIM
604481
Ensembl
ENSG00000142082
Entrez Gene
23410
UniGene
716456
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SIRT3
GeneCards
SIRT3