Cell Senescence Entries for RAD51C

Cell Types
Mammary epithelial
Cell Lines
MCF-10A
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Tumiati et al. (2017) Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers. Oncogene 35(35)4601-10 (PubMed)

RAD51C Gene Information

HGNC symbol
RAD51C 
Aliases
FANCO; RAD51L2 
Common name
RAD51 paralog C 
Entrez Id
5889
Description
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

RAD51C Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6259; DNA metabolic process
GO:6974; cellular response to DNA damage stimulus
GO:6310; DNA recombination
GO:7131; reciprocal meiotic recombination
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:724; double-strand break repair via homologous recombination
GO:707; meiotic DNA recombinase assembly
GO:722; telomere maintenance via recombination
GO:7062; sister chromatid cohesion
GO:7066; female meiosis sister chromatid cohesion
And 3 more GO terms
Cellular component: GO:5634; nucleus
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:30054; cell junction
GO:5737; cytoplasm
GO:48471; perinuclear region of cytoplasm
GO:5657; replication fork
GO:33063; Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:48476; Holliday junction resolvase complex
And 2 more GO terms
Function: GO:5524; ATP binding
GO:3677; DNA binding
GO:8094; ATPase, acting on DNA
GO:166; nucleotide binding
GO:5515; protein binding
GO:400; four-way junction DNA binding
GO:8821; crossover junction endodeoxyribonuclease activity
Show all GO terms

Homologs of RAD51C in Model Organisms

Caenorhabditis elegans
rad-51
Danio rerio
rad51c
Drosophila melanogaster
spn-D
Mus musculus
Rad51c
Rattus norvegicus
Rad51c
Saccharomyces cerevisiae
RAD51

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAD51

External links

OMIM
602774
Ensembl
ENSG00000108384
Entrez Gene
5889
UniGene
412587
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RAD51C
GeneCards
RAD51C