Cell Senescence Entries for PIAS4

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
Overexpression of PIAS4 lead to a irreversible cell growth arrest (predominantly in the G1 phase), with cells exhibiting a flat cell morphology, increased SA-beta-galactosidase activity and an increased formation of SA-heterochromatin foci.
Primary Reference

    PIAS4 Gene Information

    HGNC symbol
    PIAS4 
    Aliases
    PIASY; Piasg; ZMIZ6; PIAS-gamma 
    Common name
    protein inhibitor of activated STAT 4 
    Entrez Id
    51588
    Description

    PIAS4 Ontologies

    Gene Ontology
    Process: GO:16055; Wnt signaling pathway
    GO:6303; double-strand break repair via nonhomologous end joining
    GO:32088; negative regulation of NF-kappaB transcription factor activity
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:45892; negative regulation of transcription, DNA-templated
    GO:10804; negative regulation of tumor necrosis factor-mediated signaling pathway
    GO:1902231; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
    GO:1902174; positive regulation of keratinocyte apoptotic process
    GO:33235; positive regulation of protein sumoylation
    GO:16925; protein sumoylation
    GO:6351; transcription, DNA-templated
    And 1 more GO terms
    Cellular component: GO:16605; PML body
    GO:5737; cytoplasm
    GO:16363; nuclear matrix
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:1990234; transferase complex
    Function: GO:3677; DNA binding
    GO:61665; SUMO ligase activity
    GO:19789; SUMO transferase activity
    GO:8022; protein C-terminus binding
    GO:5515; protein binding
    GO:3714; transcription corepressor activity
    GO:31625; ubiquitin protein ligase binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of PIAS4 in Model Organisms

    Caenorhabditis elegans
    gei-17
    Danio rerio
    pias4b
    Danio rerio
    pias4a
    Mus musculus
    Pias4
    Rattus norvegicus
    Pias4
    Saccharomyces cerevisiae
    NFI1
    Saccharomyces cerevisiae
    SIZ1
    Schizosaccharomyces pombe
    pli1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as SIZ1

    External links

    OMIM
    605989
    Ensembl
    ENSG00000105229
    Entrez Gene
    51588
    UniGene
    105779
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PIAS4
    GeneCards
    PIAS4