Cell Senescence Entries for MSN
- Cell Types
- Dermal microvascular endothelial
- Cell Lines
- HDMEC
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Lee et al. (2010) Knockdown of moesin expression accelerates cellular senescence of human dermal microvascular endothelial cells. Yonsei Med J 51(3)438-47 (PubMed)
MSN Gene Information
- HGNC symbol
- MSN
- Aliases
- Common name
- moesin
- Entrez Id
- 4478
- Description
- Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008].
MSN Ontologies
- Gene Ontology
-
Process: GO:7010; cytoskeleton organization
GO:10628; positive regulation of gene expression
GO:8360; regulation of cell shape
GO:72678; T cell migration
GO:45198; establishment of epithelial cell apical/basal polarity
GO:61028; establishment of endothelial barrier
GO:8361; regulation of cell size
GO:22612; gland morphogenesis
GO:42098; T cell proliferation
GO:71394; cellular response to testosterone stimulus
GO:2000401; regulation of lymphocyte migration
And 11 more GO terms Cellular component: GO:5856; cytoskeleton
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:5615; extracellular space
GO:16324; apical plasma membrane
GO:30175; filopodium
GO:42995; cell projection
GO:71944; cell periphery
And 14 more GO terms Function: GO:3779; actin binding
GO:8092; cytoskeletal protein binding
GO:5515; protein binding
GO:5102; signaling receptor binding
GO:19901; protein kinase binding
GO:5200; structural constituent of cytoskeleton
GO:3725; double-stranded RNA binding
GO:50839; cell adhesion molecule binding
GO:19899; enzyme binding
Homologs of MSN in Model Organisms
- Caenorhabditis elegans
- erm-1
- Danio rerio
- msnb
- Danio rerio
- msna
- Drosophila melanogaster
- Moe
- Mus musculus
- Msn
- Rattus norvegicus
- Msn
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as erm-1
- GenAge microarray genes
- This gene is present as MSN
External links
- OMIM
- 309845
- Ensembl
- ENSG00000147065
- Entrez Gene
- 4478
- UniGene
- 713679
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MSN
- GeneCards
- MSN