Cell Senescence Entries for MSN

Cell Types
Dermal microvascular endothelial
Cell Lines
HDMEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2010) Knockdown of moesin expression accelerates cellular senescence of human dermal microvascular endothelial cells. Yonsei Med J 51(3)438-47 (PubMed)

MSN Gene Information

HGNC symbol
MSN 
Aliases
 
Common name
moesin 
Entrez Id
4478
Description
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008].

MSN Ontologies

Gene Ontology
Process: GO:7010; cytoskeleton organization
GO:10628; positive regulation of gene expression
GO:8360; regulation of cell shape
GO:72678; T cell migration
GO:45198; establishment of epithelial cell apical/basal polarity
GO:61028; establishment of endothelial barrier
GO:8361; regulation of cell size
GO:22612; gland morphogenesis
GO:42098; T cell proliferation
GO:71394; cellular response to testosterone stimulus
GO:2000401; regulation of lymphocyte migration
And 11 more GO terms
Cellular component: GO:5856; cytoskeleton
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:5615; extracellular space
GO:16324; apical plasma membrane
GO:30175; filopodium
GO:42995; cell projection
GO:71944; cell periphery
And 14 more GO terms
Function: GO:3779; actin binding
GO:8092; cytoskeletal protein binding
GO:5515; protein binding
GO:5102; signaling receptor binding
GO:19901; protein kinase binding
GO:5200; structural constituent of cytoskeleton
GO:3725; double-stranded RNA binding
GO:50839; cell adhesion molecule binding
GO:19899; enzyme binding
Show all GO terms

Homologs of MSN in Model Organisms

Caenorhabditis elegans
erm-1
Danio rerio
msnb
Danio rerio
msna
Drosophila melanogaster
Moe
Mus musculus
Msn
Rattus norvegicus
Msn

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as erm-1
GenAge microarray genes
  • This gene is present as MSN

External links

OMIM
309845
Ensembl
ENSG00000147065
Entrez Gene
4478
UniGene
713679
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MSN
GeneCards
MSN