Cell Senescence Entries for MRTFA

Cell Types
Liver cancer
Cell Lines
HuH6, Huh7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Hampl et al. (2014) Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. EMBO Mol Med 5(9)1367-82 (PubMed)

MRTFA Gene Information

HGNC symbol
MRTFA 
Aliases
BSAC; KIAA1438; MAL; MKL; MKL1; MRTF-A 
Common name
myocardin related transcription factor A 
Entrez Id
57591
Description
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

MRTFA Ontologies

Gene Ontology
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:10735; positive regulation of transcription via serum response element binding
GO:30036; actin cytoskeleton organization
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:51145; smooth muscle cell differentiation
GO:44319; wound healing, spreading of cells
GO:6357; regulation of transcription by RNA polymerase II
GO:43086; negative regulation of catalytic activity
Cellular component: GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5634; nucleus
Function: GO:3713; transcription coactivator activity
GO:3785; actin monomer binding
GO:3779; actin binding
GO:5515; protein binding
GO:43522; leucine zipper domain binding
GO:4864; protein phosphatase inhibitor activity
Show all GO terms

Homologs of MRTFA in Model Organisms

Danio rerio
mkl1b
Danio rerio
mkl1a
Drosophila melanogaster
Mrtf
Mus musculus
Mkl1
Rattus norvegicus
Mkl1

In other databases

LongevityMap
  • This gene is present as MKL1

External links

OMIM
606078
Ensembl
ENSG00000196588
Entrez Gene
57591
UniGene
654688
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MRTFA
GeneCards
MRTFA