Cell Senescence Entries for MORC3
- Cell Types
- Lung fibroblast
- Cell Lines
- WI-38
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Takahashi et al. (2007) Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell 18(5)1701-9 (PubMed)
MORC3 Gene Information
- HGNC symbol
- MORC3
- Aliases
- KIAA0136; NXP2; ZCW5; ZCWCC3
- Common name
- MORC family CW-type zinc finger 3
- Entrez Id
- 23515
- Description
- This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016].
MORC3 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:51457; maintenance of protein location in nucleus
GO:50821; protein stabilization
GO:7569; cell aging
GO:48147; negative regulation of fibroblast proliferation
GO:9791; post-embryonic development
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:16605; PML body
GO:16363; nuclear matrix
Show all GO termsFunction: GO:3723; RNA binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:5515; protein binding
GO:16887; ATP hydrolysis activity
GO:35064; methylated histone binding
Homologs of MORC3 in Model Organisms
- Caenorhabditis elegans
- morc-1
- Danio rerio
- morc3a
- Danio rerio
- morc3b
- Mus musculus
- Morc3
- Rattus norvegicus
- Morc3
External links
- OMIM
- 610078
- Ensembl
- ENSG00000159256
- Entrez Gene
- 23515
- UniGene
- 421150
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MORC3
- GeneCards
- MORC3