Cell Senescence Entries for MAST1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    MAST1 Gene Information

    HGNC symbol
    MAST1 
    Aliases
    SAST; SAST170 
    Common name
    microtubule associated serine/threonine kinase 1 
    Entrez Id
    22983
    Description

    MAST1 Ontologies

    Gene Ontology
    Process: GO:7010; cytoskeleton organization
    GO:35556; intracellular signal transduction
    GO:18105; peptidyl-serine phosphorylation
    GO:6468; protein phosphorylation
    Cellular component: GO:5737; cytoplasm
    GO:5856; cytoskeleton
    GO:5622; intracellular
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:287; magnesium ion binding
    GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of MAST1 in Model Organisms

    Caenorhabditis elegans
    kin-4
    Danio rerio
    mast1b
    Danio rerio
    mast1a
    Drosophila melanogaster
    dop
    Mus musculus
    Mast1
    Rattus norvegicus
    MAST1
    Saccharomyces cerevisiae
    RIM15

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as RIM15
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as RIM15

    External links

    OMIM
    612256
    Ensembl
    ENSG00000105613
    Entrez Gene
    22983
    UniGene
    227489
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAST1
    GeneCards
    MAST1