Cell Senescence Entries for MAP2K2
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Lin et al. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 12(19)3008-19 (PubMed)
MAP2K2 Gene Information
- HGNC symbol
- MAP2K2
- Aliases
- MEK2; PRKMK2
- Common name
- mitogen-activated protein kinase kinase 2
- Entrez Id
- 5605
- Description
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].
MAP2K2 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:43410; positive regulation of MAPK cascade
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:32872; regulation of stress-activated MAPK cascade
GO:90170; regulation of Golgi inheritance
GO:2000641; regulation of early endosome to late endosome transport
GO:45893; positive regulation of transcription, DNA-templated
GO:165; MAPK cascade
GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA
And 3 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5783; endoplasmic reticulum
GO:5770; late endosome
GO:5739; mitochondrion
GO:5576; extracellular region
GO:5925; focal adhesion
GO:5829; cytosol
GO:5874; microtubule
And 6 more GO terms Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
And 6 more GO terms
Homologs of MAP2K2 in Model Organisms
- Caenorhabditis elegans
- mek-2
- Danio rerio
- map2k2a
- Danio rerio
- map2k2b
- Drosophila melanogaster
- Dsor1
- Mus musculus
- Map2k2
- Rattus norvegicus
- Map2k2
- Saccharomyces cerevisiae
- PBS2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as mek-2
External links
- OMIM
- 601263
- Ensembl
- ENSG00000126934
- Entrez Gene
- 5605
- UniGene
- 465627
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MAP2K2
- GeneCards
- MAP2K2