Cell Senescence Entries for EPAS1
- Cell Types
- Bone marrow neuroblastoma
- Cell Lines
- SH-SY5Y, SK-N-BE(2)
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Cimmino et al. (2016) Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells. Sci Rep 5(2)11158 (PubMed)
EPAS1 Gene Information
- HGNC symbol
- EPAS1
- Aliases
- bHLHe73; HIF2A; HLF; MOP2; PASD2
- Common name
- endothelial PAS domain protein 1
- Entrez Id
- 2034
- Description
- This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009].
EPAS1 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:1525; angiogenesis
GO:6357; regulation of transcription by RNA polymerase II
GO:71456; cellular response to hypoxia
GO:7165; signal transduction
GO:120162; positive regulation of cold-induced thermogenesis
GO:1666; response to hypoxia
GO:2000434; regulation of protein neddylation
GO:1892; embryonic placenta development
And 17 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5667; transcription regulator complex
GO:16607; nuclear speck
GO:785; chromatin
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:46982; protein heterodimerization activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:43565; sequence-specific DNA binding
GO:1223; transcription coactivator binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
And 3 more GO terms
Homologs of EPAS1 in Model Organisms
- Caenorhabditis elegans
- hif-1
- Danio rerio
- epas1b
- Danio rerio
- epas1a
- Drosophila melanogaster
- sima
- Mus musculus
- Epas1
- Rattus norvegicus
- Epas1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as hif-1
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as hif-1
- CellAge gene expression
- This gene is present as EPAS1
External links
- OMIM
- 603349
- Ensembl
- ENSG00000116016
- Entrez Gene
- 2034
- UniGene
- 468410
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- EPAS1
- GeneCards
- EPAS1