Cell Senescence Entries for EP300
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced, Replicative
- Senescence Effect
- Induces
- Primary Reference
- Sen et al. (2019) Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell 73(4)684-698.e8 (PubMed)
EP300 Gene Information
- HGNC symbol
- EP300
- Aliases
- KAT3B; p300
- Common name
- E1A binding protein p300
- Entrez Id
- 2033
- Description
- This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].
EP300 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:7623; circadian rhythm
GO:48511; rhythmic process
GO:16573; histone acetylation
GO:6473; protein acetylation
GO:45444; fat cell differentiation
And 57 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5694; chromosome
GO:123; histone acetyltransferase complex
GO:5667; transcription regulator complex
GO:32993; protein-DNA complex
GO:32991; protein-containing complex
Show all GO termsFunction: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3713; transcription coactivator activity
GO:3677; DNA binding
GO:3712; transcription coregulator activity
GO:16746; acyltransferase activity
GO:5515; protein binding
GO:4402; histone acetyltransferase activity
GO:3684; damaged DNA binding
GO:140297; DNA-binding transcription factor binding
And 28 more GO terms
Homologs of EP300 in Model Organisms
- Caenorhabditis elegans
- cbp-2
- Caenorhabditis elegans
- cbp-1
- Caenorhabditis elegans
- F40F12.7
- Drosophila melanogaster
- nej
- Mus musculus
- Ep300
- Rattus norvegicus
- Ep300
- Saccharomyces cerevisiae
- BDF2
- Saccharomyces cerevisiae
- BDF1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as CELE_F40F12.7
- GenAge human genes
- This gene is present as EP300
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as cbp-1
External links
- OMIM
- 602700
- Ensembl
- ENSG00000100393
- Entrez Gene
- 2033
- UniGene
- 655211
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- EP300
- GeneCards
- EP300