Cell Senescence Entries for BTG3

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Lin et al. (2012) Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis. Oncogene 31(27)3287-97 (PubMed)

BTG3 Gene Information

HGNC symbol
BTG3 
Aliases
ANA; ANA/BTG3; APRO4; tob55 
Common name
BTG anti-proliferation factor 3 
Entrez Id
10950
Description
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

BTG3 Ontologies

Gene Ontology
Process: GO:8285; negative regulation of cell population proliferation
GO:45930; negative regulation of mitotic cell cycle
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
Function: GO:5515; protein binding
Show all GO terms

Homologs of BTG3 in Model Organisms

Danio rerio
btg3
Drosophila melanogaster
Tob
Mus musculus
Gm7334
Mus musculus
Btg3
Rattus norvegicus
Btg3

In other databases

LongevityMap
  • This gene is present as BTG3

External links

OMIM
605674
Ensembl
ENSG00000154640
Entrez Gene
10950
UniGene
473420
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BTG3
GeneCards
BTG3