Cell Senescence Entries for BHLHE40
- Cell Types
- Breast cancer, Esophageal cancer
- Cell Lines
- EC9706, MCF-7
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Induces
- Observations
- BHLHE40 overexpression induced cellular senescence and inhibited cell growth and colony formation in esophageal cancer cells (EC9706).
- Primary Reference
- Cell Types
- Breast cancer, Esophageal cancer
- Cell Lines
- EC9706, MCF-7
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Induces
- Observations
- BHLHE40 overexpression induced cellular senescence and inhibited cell growth and colony formation in esophageal cancer cells (EC9706).
- Primary Reference
BHLHE40 Gene Information
- HGNC symbol
- BHLHE40
- Aliases
- DEC1; HLHB2; BHLHB2; Clast5; SHARP2; STRA13; Stra14; SHARP-2
- Common name
- basic helix-loop-helix family member e40
- Entrez Id
- 8553
- Description
- This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]
BHLHE40 Ontologies
- Gene Ontology
-
Process: GO:32922; circadian regulation of gene expression
GO:43153; entrainment of circadian clock by photoperiod
GO:43433; negative regulation of sequence-specific DNA binding transcription factor activity
GO:122; negative regulation of transcription from RNA polymerase II promoter
GO:45892; negative regulation of transcription, DNA-templated
GO:6355; regulation of transcription, DNA-templated
GO:6351; transcription, DNA-templated
Cellular component: GO:5737; cytoplasm
GO:16604; nuclear body
GO:5634; nucleus
Function: GO:70888; E-box binding
GO:43426; MRF binding
GO:1102; RNA polymerase II activating transcription factor binding
GO:981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:43425; bHLH transcription factor binding
GO:5515; protein binding
GO:19904; protein domain specific binding
GO:46982; protein heterodimerization activity
GO:42803; protein homodimerization activity
GO:3714; transcription corepressor activity
GO:3705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
And 4 more GO terms
Homologs of BHLHE40 in Model Organisms
External links
- OMIM
- 604256
- Ensembl
- ENSG00000134107
- Entrez Gene
- 8553
- UniGene
- 744856
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- BHLHE40
- GeneCards
- BHLHE40