Cell Senescence Entries for ATM
- Cell Types
- Foreskin fibroblast, Lung fibroblast
- Cell Lines
- BJ, MRC-5, WI-38
- Cancer Cell?
- No
- Method
- Knockout
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Vaziri et al. (1997) ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J 16(19)6018-33 (PubMed)
ATM Gene Information
- HGNC symbol
- ATM
- Aliases
- ATA; ATC; ATD; ATDC; TEL1; TELO1
- Common name
- ATM serine/threonine kinase
- Entrez Id
- 472
- Description
- The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010].
ATM Ontologies
- Gene Ontology
-
Process: GO:10628; positive regulation of gene expression
GO:7049; cell cycle
GO:16310; phosphorylation
GO:77; DNA damage checkpoint signaling
GO:6974; cellular response to DNA damage stimulus
GO:6281; DNA repair
GO:723; telomere maintenance
GO:6468; protein phosphorylation
GO:43065; positive regulation of apoptotic process
GO:80135; regulation of cellular response to stress
GO:724; double-strand break repair via homologous recombination
And 72 more GO terms Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:31410; cytoplasmic vesicle
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5856; cytoskeleton
GO:5730; nucleolus
GO:5813; centrosome
GO:5819; spindle
GO:5815; microtubule organizing center
And 4 more GO terms Function: GO:44877; protein-containing complex binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:4672; protein kinase activity
And 5 more GO terms
Homologs of ATM in Model Organisms
- Caenorhabditis elegans
- atm-1
- Danio rerio
- atm
- Drosophila melanogaster
- tefu
- Mus musculus
- Atm
- Rattus norvegicus
- Atm
- Saccharomyces cerevisiae
- TEL1
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Atm
- GenAge human genes
- This gene is present as ATM
- LongevityMap
- This gene is present as ATM
External links
- OMIM
- 607585
- Ensembl
- ENSG00000149311
- Entrez Gene
- 472
- UniGene
- 367437
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ATM
- GeneCards
- ATM