Cell Senescence Entries for ASPH

Cell Types
Liver cancer
Cell Lines
FOCUS, Hep G2, Huh7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Iwagami et al. (2016) Aspartate β-hydroxylase modulates cellular senescence through glycogen synthase kinase 3β in hepatocellular carcinoma. Hepatology 63(4)1213-26 (PubMed)

ASPH Gene Information

HGNC symbol
ASPH 
Aliases
BAH; CASQ2BP1; HAAH; JCTN 
Common name
aspartate beta-hydroxylase 
Entrez Id
444
Description
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009].

ASPH Ontologies

Gene Ontology
Process: GO:18193; peptidyl-amino acid modification
GO:42264; peptidyl-aspartic acid hydroxylation
GO:22900; electron transport chain
GO:6936; muscle contraction
GO:7389; pattern specification process
GO:8285; negative regulation of cell population proliferation
GO:31647; regulation of protein stability
GO:35108; limb morphogenesis
GO:45862; positive regulation of proteolysis
GO:60021; roof of mouth development
GO:60325; face morphogenesis
GO:97202; activation of cysteine-type endopeptidase activity
GO:1901879; regulation of protein depolymerization
GO:70588; calcium ion transmembrane transport
GO:71277; cellular response to calcium ion
GO:33198; response to ATP
GO:10524; positive regulation of calcium ion transport into cytosol
GO:31585; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:45893; positive regulation of transcription, DNA-templated
GO:90316; positive regulation of intracellular protein transport
GO:55074; calcium ion homeostasis
GO:32237; activation of store-operated calcium channel activity
GO:5513; detection of calcium ion
GO:10649; regulation of cell communication by electrical coupling
GO:10880; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:10881; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:60316; positive regulation of ryanodine-sensitive calcium-release channel activity
GO:60314; regulation of ryanodine-sensitive calcium-release channel activity
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:16529; sarcoplasmic reticulum
GO:33017; sarcoplasmic reticulum membrane
GO:32541; cortical endoplasmic reticulum
GO:5737; cytoplasm
GO:30176; integral component of endoplasmic reticulum membrane
GO:14701; junctional sarcoplasmic reticulum membrane
GO:33018; sarcoplasmic reticulum lumen
GO:34704; calcium channel complex
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5509; calcium ion binding
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:62101; peptidyl-aspartic acid 3-dioxygenase activity
GO:5198; structural molecule activity
GO:9055; electron transfer activity
GO:8307; structural constituent of muscle
GO:44325; transmembrane transporter binding
Hide GO terms

Homologs of ASPH in Model Organisms

Caenorhabditis elegans
K09A9.6
Danio rerio
ASPH
Drosophila melanogaster
Asph
Mus musculus
Asph

External links

OMIM
600582
Ensembl
ENSG00000198363
Entrez Gene
444
UniGene
332422
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ASPH
GeneCards
ASPH