LongevityMap Gene

Gene details

HGNC symbol
YY1 
Aliases
DELTA; NF-E1; UCRBP; INO80S; YIN-YANG-1 
Common name
YY1 transcription factor 
Description
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
Cytogenetic Location
14q32.2
UCSC Genome Browser
View 14q32.2 on the UCSC genome browser
OMIM
600013
Ensembl
ENSG00000100811
UniProt/Swiss-Prot
TYY1_HUMAN
Entrez Gene
7528
UniGene
388927
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
yy1a
Drosophila melanogaster
pho
Mus musculus
Yy1
Rattus norvegicus
Yy1

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
Dutch
Study Design
1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
Conclusions
As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
Indentifier
YY1
Reference