LongevityMap Gene

Gene details

HGNC symbol
TNF 
Aliases
DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha 
Common name
tumor necrosis factor 
Description
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Cytogenetic Location
6p21.33
UCSC Genome Browser
View 6p21.33 on the UCSC genome browser
OMIM
191160
Ensembl
ENSG00000232810
UniProt/Swiss-Prot
Q5STB3_HUMAN
Entrez Gene
7124
UniGene
241570
1000 Genomes
1000 Genomes

Homologs in model organisms

Mus musculus
Tnf
Rattus norvegicus
Tnf

In other databases

GenAge human genes
  • This gene is present as TNF

Studies (11)

Significant/Non-significant: 3/8

Study 1

Longevity Association
Non-significant
Population
Italian
Study Design
Promoter -308 G/A SNP was examined in 72 centenarian men, 102 centenarian women and healthy unrelated controls (115 men and 112 women, aged 22-60 years)
Conclusions
The genotypic frequencies 308G and 308A, suggested to be associated with low and high TNF alpha production respectively, were not significantly different between centenarians and controls
Indentifier
-308G/A
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Irish (Belfast)
    Study Design
    100 control samples (59% female, 41% male with an age-range of 19-45 years old) and 93 aged samples (70% female, 30% male with an age-range of 80-97 years old) were examined for the -308A/G SNP
    Conclusions
    No age-related allele or genotype frequencies were observed
    Indentifier
    -308G/A
    Reference

      Study 3

      Longevity Association
      Non-significant
      Population
      Bulgarian
      Study Design
      Promoter -308 (G/A) SNP was examined in 17 unrelated elderly (age 65-90 years; 6 males and 11 females), 23 family members (age 18-57 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 25-53 years (40 male and 65 female)
      Conclusions
      No significant differences relative to longevity were found
      Indentifier
      -308G/A
      Reference

        Study 4

        Longevity Association
        Non-significant
        Population
        Danish
        Study Design
        The -308 G/A SNP was examined in 122 centenarians, 174 octogenarians and 47 healthy volunteers aged 18 to 30
        Conclusions
        The distribution of TNF-308 genotypes was not different across the three different age groups, but the GA genotype was associated with decreased prevalence of dementia in centenarians. The few centenarians with AA carrier status had higher mortality risk and tended to show higher plasma levels of TNF-alpha.
        Indentifier
        -308G/A
        Reference

          Study 5

          Longevity Association
          Significant
          Population
          Mexican
          Study Design
          The frequency of the -308 polymorphism was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years).
          Conclusions
          The TNF2 allele was increased in the elder group when compared to young controls
          Indentifier
          -308G/A
          Reference

            Study 6

            Longevity Association
            Non-significant
            Population
            Japanese
            Study Design
            -1031 T/C SNP was evaluated with age or gender in 500 Japanese persons (mean age: 56.7 years old, range: 19-100)
            Conclusions
            Though not statistically significant, the -1031 T/C polymorphism may be associated with age
            Indentifier
            -1031T/C
            Reference

              Study 7

              Longevity Association
              Non-significant
              Population
              Jordanian
              Study Design
              IL-10 -1028 G/A and TNF-alpha-308 G/A were genotyped in 119 randomly selected elderly subjects (41 women and 78 men) with a mean age of 90.2 years and young control subjects of 118 (46 women and 72 men) with a mean age of 31.9 years
              Conclusions
              No significant differences were found in the genotype and allele frequencies of TNF-alpha gene variants between the two groups (P > 0.05). IL-10 genotype and allele frequencies were significantly associated with longevity in men (P < 0.05) but not in women (P < 0.05).
              Indentifier
              -308G/A
              Reference

                Study 8

                Longevity Association
                Significant
                Population
                Italian (Central)
                Study Design
                Functional SNPs have been determined for 1071 unrelated healthy individuals (502 males and 569 females) from Central Italy, 18-106 years old, divided into three gender-specific age classes defined according to demographic information and accounting for the different survivals between sexes. The categories for men were: individuals <66 years old, individuals 66-88 years old, and individuals > 88 years old. The categories for women were: individuals <73 years old, individuals 73-91 years old, and individuals > 91 years old.
                Conclusions
                When comparing all 3 age groups, both two-loci and three-loci interaction are significantly associated with life-expectancy in males. For females, a significant two-loci interaction occurs in females between ADA 22G>A (rs73598374) and TNF-a 238G>A (rs361525) only when comparing young and mid-aged individuals.
                Indentifier
                rs1800629
                Reference

                  Study 9

                  Longevity Association
                  Non-significant
                  Population
                  Italian (Southern)
                  Study Design
                  A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
                  Conclusions
                  After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
                  Indentifier
                  rs1800629
                  Reference

                    Study 10

                    Longevity Association
                    Significant
                    Population
                    Italian
                    Study Design
                    The TNF(A/G)-308 was genotyped in 747 subjects (401 women, ages: 19–110 years) to study the association with longevity
                    Conclusions
                    TNF region was associated with life expectancy (P = 0.0027). Allele A of TNF(A/G)-308 had a detrimental effect on life expectancy, and this effect is specific to men.
                    Indentifier
                    -308G/A
                    Reference

                      Study 11

                      Longevity Association
                      Non-significant
                      Population
                      Finnish
                      Study Design
                      250 (52 males and 198 females) nonagenarians and 400 healthy control group (18-60 years old) were examined for -308 SNP
                      Conclusions
                      No significant differences relative to longevity were found
                      Indentifier
                      -308G/A
                      Reference