LongevityMap Gene

Gene details

HGNC symbol
TAS2R5 
Aliases
T2R5 
Common name
taste 2 receptor member 5 
Description
This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser
OMIM
605062
Ensembl
ENSG00000127366
UniProt/Swiss-Prot
A4D1U0_HUMAN
Entrez Gene
54429
UniGene
675370
1000 Genomes
1000 Genomes

Homologs in model organisms

No homologs found

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Italian (Southern)
Study Design
Using a tagging approach, the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 unrelated individuals (20-106 years old) was investigated. The study included 348 very elderly cases (>=85 years, mean age 93.82 years, median age 92) and 593 non-elderly controls (<85 years, mean age 59.17 years, median age 67 years).
Conclusions
None of the tested single nucleotide polymorphisms, excepting rs978739, showed a significant association with the longevity phenotype
Indentifier
rs2227264
Reference