LongevityMap Gene

Gene details

HGNC symbol
SYT13 
Aliases
 
Common name
synaptotagmin 13 
Description
This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Cytogenetic Location
11p11.2
UCSC Genome Browser
View 11p11.2 on the UCSC genome browser
OMIM
607716
Ensembl
ENSG00000019505
UniProt/Swiss-Prot
SYT13_HUMAN
Entrez Gene
57586
UniGene
436643
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
syt13
Mus musculus
Syt13
Rattus norvegicus
Syt13

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
American (Caucasian)
Study Design
Genome-wide association study in 801 centenarians and 914 healthy controls
Conclusions
281 SNPs were found to discriminate between cases and controls
Indentifier
rs4755936
Reference