LongevityMap Gene

Gene details

HGNC symbol
SUCLA2 
Aliases
A-SCS; A-BETA; MTDPS5; SCS-betaA 
Common name
succinate-CoA ligase ADP-forming beta subunit 
Description
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
Cytogenetic Location
13q14.2
UCSC Genome Browser
View 13q14.2 on the UCSC genome browser
OMIM
603921
Ensembl
ENSG00000136143
UniProt/Swiss-Prot
E5KS60_HUMAN
Entrez Gene
8803
UniGene
743361
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
F47B10.1
Danio rerio
sucla2
Drosophila melanogaster
skap
Mus musculus
Sucla2
Rattus norvegicus
Sucla2
Saccharomyces cerevisiae
LSC2
Schizosaccharomyces pombe
SPCC1620.08

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as LSC2

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
European
Study Design
Meta-analysis of genome-wide association studies of survival and survival free of major disease or death. In total, there were 25,007 participants over 55 years of age and followed-up for over 10 years for mortality and over 8 years for event-free survival.
Conclusions
No SNP was significantly associated with time to event after correcting for multiple testing, but 8 independent SNPs predicted event-free survival at a suggestive threshold
Indentifier
rs8001976
Reference