LongevityMap Gene
Gene details
- HGNC symbol
- SOS1
- Aliases
- GF1; HGF; NS4; GGF1; GINGF
- Common name
- SOS Ras/Rac guanine nucleotide exchange factor 1
- Description
- This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 2p22.1
- UCSC Genome Browser
- View 2p22.1 on the UCSC genome browser
- OMIM
- 182530
- Ensembl
- ENSG00000115904
- UniProt/Swiss-Prot
- G5E9C8_HUMAN
- Entrez Gene
- 6654
- UniGene
- 709893
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- sos-1
- Danio rerio
- sos1
- Drosophila melanogaster
- Sos
- Mus musculus
- Sos1
- Rattus norvegicus
- Sos1
- Saccharomyces cerevisiae
- CDC25
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as CDC25
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as CDC25
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs1059310
- Reference