LongevityMap Gene

Gene details

HGNC symbol
SORCS2 
Aliases
 
Common name
sortilin related VPS10 domain containing receptor 2 
Description
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]
Cytogenetic Location
4p16.1
UCSC Genome Browser
View 4p16.1 on the UCSC genome browser
OMIM
606284
Ensembl
ENSG00000184985
UniProt/Swiss-Prot
SORC2_HUMAN
Entrez Gene
57537
UniGene
479099
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
sorcs2
Mus musculus
Sorcs2
Rattus norvegicus
Sorcs2

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
American (Caucasian)
Study Design
Genome-wide association study in 801 centenarians and 914 healthy controls
Conclusions
281 SNPs were found to discriminate between cases and controls
Indentifier
rs6812745
Reference