LongevityMap Gene

Gene details

HGNC symbol
SDC4 
Aliases
SYND4 
Common name
syndecan 4 
Description
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Cytogenetic Location
20q13.12
UCSC Genome Browser
View 20q13.12 on the UCSC genome browser
OMIM
600017
Ensembl
ENSG00000124145
UniProt/Swiss-Prot
B4E1S6_HUMAN
Entrez Gene
6385
UniGene
632267
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
sdc4
Mus musculus
Sdc4
Rattus norvegicus
Sdc4

Studies (2)

Significant/Non-significant: 1/1

Study 1

Longevity Association
Significant
Population
Italian (Southern)
Study Design
11 SNPs within the SDC4 gene were tested for association with longevity in a cohort of 624 unrelated subjects (aged 64-107, 287 males and 337 females, 350 subjects > 85 years old). Then the identified longevity-associated SNPs were correlated with metabolic parameters in the subgroup of 64-85 years old.
Conclusions
rs1981429 was negatively associated with longevity (adjusted p = 0.028), high levels of triglycerides (adjusted p = 0.028) and low levels of LDL-C (adjusted p = 0.009). rs2251252 was positively correlated with longevity (adjusted p = 0.018) and high LDL-C (adjusted p = 0.022).
Indentifier
rs1981429
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Italian (Southern)
    Study Design
    11 SNPs within the SDC4 gene were tested for association with longevity in a cohort of 624 unrelated subjects (aged 64-107, 287 males and 337 females, 350 subjects > 85 years old). Then the identified longevity-associated SNPs were correlated with metabolic parameters in the subgroup of 64-85 years old.
    Conclusions
    After multiple test correction, those 9 SNPs were not associated with longevity or other metabolic parameters.
    Indentifier
    rs2228384
    Reference