LongevityMap Gene

Gene details

HGNC symbol
RPS6 
Aliases
S6 
Common name
ribosomal protein S6 
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Cytogenetic Location
9p22.1
UCSC Genome Browser
View 9p22.1 on the UCSC genome browser
OMIM
180460
Ensembl
ENSG00000137154
UniProt/Swiss-Prot
A2A3R6_HUMAN
Entrez Gene
6194
UniGene
408073
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
rps-6
Danio rerio
zgc:92237
Drosophila melanogaster
RpS6
Mus musculus
Rps6
Rattus norvegicus
Rps6
Saccharomyces cerevisiae
RPS6A
Schizosaccharomyces pombe
rps6b

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as rps-6
  • A homolog of this gene for Saccharomyces cerevisiae is present as RPS6A

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
Dutch
Study Design
1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
Conclusions
As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
Indentifier
RPS6
Reference