LongevityMap Gene

Gene details

HGNC symbol
RHOBTB3 
Aliases
 
Common name
Rho related BTB domain containing 3 
Description
RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM, Apr 2004]
Cytogenetic Location
5q15
UCSC Genome Browser
View 5q15 on the UCSC genome browser
OMIM
607353
Ensembl
ENSG00000164292
UniProt/Swiss-Prot
RHBT3_HUMAN
Entrez Gene
22836
UniGene
445030
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
si:dkey-6b12.5
Mus musculus
Rhobtb3
Rattus norvegicus
Rhobtb3

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Italian
Study Design
Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
Conclusions
A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
Indentifier
rs888808
Reference