LongevityMap Gene

Gene details

HGNC symbol
RHEB 
Aliases
RHEB2 
Common name
Ras homolog enriched in brain 
Description
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
OMIM
601293
Ensembl
ENSG00000106615
UniProt/Swiss-Prot
A0A090N900_HUMAN
Entrez Gene
6009
UniGene
283521
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
rhebl1
Drosophila melanogaster
Rheb
Mus musculus
Rheb
Rattus norvegicus
Rheb
Schizosaccharomyces pombe
rhb1

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
Dutch
Study Design
1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
Conclusions
As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
Indentifier
RHEB
Reference