LongevityMap Gene
Gene details
- HGNC symbol
- REN
- Aliases
- HNFJ2
- Common name
- renin
- Description
- Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 1q32.1
- UCSC Genome Browser
- View 1q32.1 on the UCSC genome browser
- OMIM
- 179820
- Ensembl
- ENSG00000143839
- UniProt/Swiss-Prot
- RENI_HUMAN
- Entrez Gene
- 5972
- UniGene
- 3210
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- asp-3
- Caenorhabditis elegans
- asp-4
- Danio rerio
- ren
- Drosophila melanogaster
- cathD
- Drosophila melanogaster
- CG10104
- Mus musculus
- Ren1
- Mus musculus
- Ren1
- Rattus norvegicus
- Ren
- Saccharomyces cerevisiae
- PEP4
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Polymorphic repeats in intron 7 (Short and Long alleles) were examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old)
- Conclusions
- No significant difference in genotypic frequencies was found between centenarians and controls
- Indentifier
- REN
- Reference