LongevityMap Gene

Gene details

HGNC symbol
RAPGEF4 
Aliases
EPAC; CGEF2; EPAC2; EPAC; 2; Nbla00496; CAMP-GEFII 
Common name
Rap guanine nucleotide exchange factor 4 
Description
Cytogenetic Location
2q31.1
UCSC Genome Browser
View 2q31.1 on the UCSC genome browser
OMIM
606058
Ensembl
ENSG00000091428
UniProt/Swiss-Prot
B7Z278_HUMAN
Entrez Gene
11069
UniGene
470646
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
rapgef4
Drosophila melanogaster
Epac
Mus musculus
Rapgef4

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
German
Study Design
Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
Conclusions
Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
Indentifier
rs6433379
Reference